Isoxsuprine hydrochloride

Research use only, not for human use.

A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.

A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor. (In Vitro):Results show that Isoxsuprine hydrochloride inhibits circular chemorepellent induced defect (CCID) formation dose dependently (5 to 60?μM) and also inhibits 12(S)-HETE synthesis. Furthermore, Isoxsuprine hydrochloride is the only drug inhibiting the induction of all three mobility markers (MLC2, MYPT and paxillin).(In Vivo):Total infarct volume in vehicle-treated animals is 279±25 mm3 compare to 137±18 mm3 in Isoxsuprine hydrochloride-treated animals.

Results show that Isoxsuprine hydrochloride inhibits circular chemorepellent induced defect (CCID) formation dose dependently (5 to 60?μM) and also inhibits 12(S)-HETE synthesis. Furthermore, Isoxsuprine hydrochloride is the only drug inhibiting the induction of all three mobility markers (MLC2, MYPT and paxillin).

Total infarct volume in vehicle-treated animals is 279±25 mm3 compare to 137±18 mm3 in Isoxsuprine hydrochloride-treated animals.

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Endocrinology/Hormones

Adrenergic Receptor

β-adrenergic receptor

Cardiovascular Disease

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579-56-6

337.84

C18H24ClNO3

>98% (HPLC)

Soluble in Water

Cl.CC(COC1=CC=CC=C1)NC(C)C(O)C1=CC=C(O)C=C1

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(-20℃)

With Ice Pack

≥ 2 years